Effect of flunixin or ketoprofen in caudectomy by elastration in lambs: pain and neutrophil function

ABSTRACT: Painful procedures can affect the function of innate immune cells, such as neutrophils and macrophages, increasing risk infectious diseases. The present work aimed to verify if analgesics flunixin meglumine or ketoprofen attenuate pain/discomfort newborn lambs submitted by elastration tail docking thereby avoid impairment blood granulocytes function. Twenty-one neonate were divided into three treatments: control group (n=7), not subjected caudectomy; caudectomy under local anesthesia analgesia with two doses meglumine; ketoprofen. Pain indicators observed pain posture score (PS), number vocalizations (V), frequency movement ears (EF), respiratory rates (RR), a 10 minutes videos for each time points: -15min, 6h, 48h, 144h. At same points, reactive oxygen species (ROS) production phagocytosis measured flow cytometry. 6h after caudectomy, there was indicator increase (RR, V, PS), granulocyte percentage increase, reduction both groups. spend more in and, at 144h, they exhibited ROS without signs pain. We conclude did prevent acute caused because groups showed behavior impaired response however, effective controlling chronic their effects on compare